I obtained my BS in Chemical Engineering at the University of Maryland, College Park in May 2006 and my PhD in Bioengineering at the University of Maryland, College Park in December 2010. My PhD thesis focused on using dendrimers for oral drug delivery of poorly bioavailable chemotherapy drugs and was conducted under Drs. Hamid Ghandehari and Peter Swaan at the University of Maryland, Baltimore.
After my PhD, I joined MedImmune (now AstraZeneca) where I worked as a scientist in Formulation Sciences from 2010-2016. At MedImmune, I served on cross-functional project teams for multiple early and mid-stage clinical programs, completing formulation development, regulatory filings and drug product manufacturing technology transfer for monoclonal antibodies, antibody-drug conjugates and fusion proteins. I also led technical development projects focused on predictability of high throughput technologies for protein aggregation, photosensitive monoclonal antibodies, development of ultrahigh concentration lyophilized drug products and formulation of monoclonal antibodies with low isoelectric points. |
In August 2016 I made a career change, joining the Department of Chemical & Biomolecular Engineering at the University of Maryland as a lecturer. From Fall 2016 to Spring 2023, I taught seven courses om chemical engineering, including developing a new elective course "Biopharmaceutical Process Development & Manufacturing" and a new freshman seminar "CHBE 100: Exploring ChBE." In addition to coursework, I am passionate about mentoring students, helping them with strategies for academic success and career preparation. I am also invested in helping to create an engineering culture which is supportive and inclusive of students from a wide range of diverse backgrounds. I engage in and publish educational research to better understand the impact of pedagogical practices I implement in the classroom. In Fall 2023, I moved to the Fischell Department of Bioengineering.
Outside of work I enjoy cooking and baking, running, and spending time with my husband, two daughters and cat, Beaker.
Outside of work I enjoy cooking and baking, running, and spending time with my husband, two daughters and cat, Beaker.
Publications
Engineering Education
Formulation & Drug Delivery
- S. Wilson and D. Goldberg, Strategies for Supporting Engineering Student Mental Health. Chemical Engineering Education, 57(2), 2023.
- D. Goldberg and G. Sriram. Assessment of Short and Longer-term Impacts of a 1-credit Chemical Engineering First-Year Seminar. Chemical Engineering Education, 56(3), 2022.
- D. Goldberg, Incorporation of Research & Development-Focused Professional Skills in a Chemical Engineering Elective Course. 129th Annual American Society of Engineering Education Conference & Exposition. Minneapolis, Minnesota, June 26-29, 2022.
- D. Goldberg, Fostering Student Engagement and Effective Online Learning during the COVID-19 Pandemic. Chemical Engineering Education, 54(4), 177, 2020.
- D. Goldberg, “Help me help you”: Implementing reference request guidelines to improve the recommendation letter process. Chemical Engineering Education, 54(1), 32-24, 2020.
- D. Goldberg, J. Zou and G. Sriram. Design, Implementation and Evaluation of a 1-credit Chemical Engineering First-Year Seminar. 126th Annual American Society of Engineering Education Conference & Exposition. Tampa, FL, June 15-19, 2019.
Formulation & Drug Delivery
- D. Goldberg, R. Lewus, R. Esfandiary, D. Farkas, N. Mody, K. Day, P. Mallik, T. M. Tracka, S. Sealey and H. Samra. Utility of High Throughput Screening Techniques to Predict Stability of Monoclonal Antibody Formulations During Early Stage Development. J. Pharm. Sci, 106(8): 1971-1977, 2017.
- J. Jayaraman, J. Wu, M. Brunelle, A. Cruz, D. Goldberg, B. Lobo, A. Shah and P. Tessier. Plasmonic measurements of monoclonal antibody self-association using self-interaction nanoparticle spectroscopy. Biotechnol. & Bioeng, 111(8): 1512-1520, 2014.
- D. Goldberg, V. Nirmalkumar, P. Swaan and H. Ghandehari. G3.5 PAMAM Dendrimer-SN38 Conjugates Enhance Transepithelial Transport of SN38 while minimizing Gastrointestinal Toxicity and Release. J Control Release, 150(3):318-325, 2011.
- D. Goldberg, S. Bishop, A. Shah and H. Sathish, Formulation Development of Therapeutic Monoclonal Antibodies using High-throughput Fluorescence and Static Light Scattering Techniques: Role of Conformational and Colloidal Stability, J Pharm Sci, 100(4): 1306-1315, 2011.
- D. Goldberg, H. Ghandehari and P. Swaan, Cellular entry of G3.5 PAMAM dendrimers by clathrin- and dynamin- dependent endocytosis is required for tight junctional opening in intestinal epithelia, Pharm Res, 27(8) (2010) 1547-57.
- D. Sweet, R. Kolhatkar, A. Ray, P. Swaan, and H. Ghandehari, Transepithelial transport of PEGylated anionic poly(amidoamine) dendrimers: implications for oral drug delivery. J Control Release 138(1) (2009) 78-85.
- R. Kolhatkar, D. Sweet, and H. Ghandehari, Functionalized Dendrimers as Nanoscale Drug Carriers, in Multifunctional Pharmaceutical Nanocarriers, Springer 201-232, 2008.
- M. Al-Sheikhly, D. Sweet, L. Salamanca-Riba, B. Varughese, J. Silverman, A. Christou, and W. Bentley, Radiation-induced failure mechanisms of GaAs-based biochips, IEEE, Device and Materials Reliability, 4, (2004) 192-197.